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HPLC-MS/MS analysis of ilimaquinone and its application in a pharmacokinetic study in rats
- Authors
- Son, Heebin; Noh, Keumhan; Kang, Changhyun; Na, MinKyun; Oh, Sangtaek; Song, Im-Sook; Kang, Wonku
- Issue Date
- Mar-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Ilimaquinone; LC-MS/MS; Rat plasma; Stability
- Citation
- JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v.166, pp 291 - 294
- Pages
- 4
- Journal Title
- JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Volume
- 166
- Start Page
- 291
- End Page
- 294
- ISSN
- 0731-7085
1873-264X
- Abstract
- Ilimaquinone, a metabolite isolated from the marine sponge Hippiospongia metachromia, has antimicrobial, cytotoxic, anti-HIV, anti-inflammatory, and anti-cancer activities. A new quantitative analytical method for determination of ilimaquinone in rat plasma using HPLC-MS/MS was developed and validated. Ascorbic acid was added to ensure the stability of ilimaquinone in plasma. After protein precipitation using acetonitrile plus diclofenac as an internal standard, the analytes were chromatographed on a biphenyl column with a mobile phase of methanol and water (8:2, v/v, including 0.1% formic acid). This method was successfully applied in a pharmacokinetic study of ilimaquinone after oral administration in rats. (C) 2019 Elsevier B.V. All rights reserved.
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