Novel Hg2+-Selective Signaling Probe Based on Resorufin Thionocarbonate and its mu PAD Applicationopen access
- Authors
- Choi, Myung Gil; Park, So Young; Park, Ka Young; Chang, Suk-Kyu
- Issue Date
- Mar-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.9, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18124
- DOI
- 10.1038/s41598-019-40169-6
- ISSN
- 2045-2322
- Abstract
- In this study, a novel resorufin thionocarbonate-based Hg2+-selective signaling probe (RT) for microfluidic paper-based analytical device (mu PAD) applications is reported. The designed probe, RT, was readily synthesized by the one-step reaction of resorufin with phenyl thionochloroformate. The RT probe displayed a prominent color change from yellow to pink and a marked turn-on fluorescence signaling behavior exclusively toward the Hg2+ ion. The signaling of RT was due to Hg2+-induced hydrolysis of the phenyl thionocarbonate moiety to form the parent resorufin dye, which restored its spectroscopic properties. In addition, RT exhibited the Hg2+-selective signaling behavior without interference by coexisting environmentally relevant metal ions. The detection limit for Hg2+ in simulated wastewater samples was estimated to be 5.8 x 10(-8) M. In particular, an RT-equipped mu PAD prepared using a wax printing technique enabled simple and convenient determination of Hg2+ ions in simulated wastewater samples, with a detection limit of 5.9 x 10(-6) M.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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