Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signalingopen access
- Authors
- Lee, Donghee; Seo, Yelim; Kim, Young-Won; Kim, Seongtae; Bae, Hyemi; Choi, Jeongyoon; Lim, Inja; Bang, Hyoweon; Kim, Jung-Ha; Ko, Jae-Hong
- Issue Date
- Mar-2019
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Cell movement; Infrared rays; Integrins; Microarray analysis; Platelet-derived growth factor
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.23, no.2, pp 141 - 150
- Pages
- 10
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 23
- Number
- 2
- Start Page
- 141
- End Page
- 150
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18167
- DOI
- 10.4196/kjpp.2019.23.2.141
- ISSN
- 1226-4512
2093-3827
- Abstract
- Despite increased evidence of bio-activity following far-infrared (FIR) radiation, susceptibility of cell signaling to FIR radiation-induced homeostasis is poorly understood. To observe the effects of FIR radiation, FIR-radiated materials-coated fabric was put on experimental rats or applied to L6 cells, and microarray analysis, quantitative real-time polymerase chain reaction, and wound healing assays were performed. Microarray analysis revealed that messenger RNA expressions of rat muscle were stimulated by FIR radiation in a dose-dependent manner in amount of 10% and 30% materials-coated. In 30% group, 1,473 differentially expressed genes were identified (fold change (FC] > 1.5), and 218 genes were significantly regulated (FC > 1.5 and p < 0.05). Microarray analysis showed that extracellular matrix (ECM)-receptor interaction, focal adhesion, and cell migration-related pathways were significantly stimulated in rat muscle. ECM and platelet-derived growth factor (PDGF)-mediated cell migration-related genes were increased. And, results showed that the relative gene expression of actin beta was increased. FIR radiation also stimulated actin subunit and actin-related genes. We observed that wound healing was certainly promoted by FIR radiation over 48 h in L6 cells. Therefore, we suggest that FIR radiation can penetrate the body and stimulate PDGF-mediated cell migration through ECM-integrin signaling in rats.
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