Metabolomic Screening of Anti-Inflammatory Compounds from the Leaves of Actinidia arguta (Hardy Kiwi)
DC Field | Value | Language |
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dc.contributor.author | Kim, Gyoung-Deuck | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Auh, Joong-Hyuck | - |
dc.date.available | 2019-05-28T01:39:31Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2304-8158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18292 | - |
dc.description.abstract | The metabolomic screening of potential anti-inflammatory compounds in the leaves of Actinidia arguta was performed by using LC-MS/MS. Ethanol extracts were prepared, and the anti-inflammatory effects were investigated based on nitric oxide (NO) synthesis and inducible nitric oxide synthase expression in lipopolysaccharide-induced RAW 264.7 macrophages. The 75% ethanol extract showed the highest inhibitory effect on nitric oxide (NO) production, and it was further separated by in vitro bioassay-guided fractionation using preparative LC with reversed-phase column separation. Through multiple steps of fractionation, sub-fraction 1-3 was finally purified, and caffeic acid derivatives, such as caffeoylthreonic acid and danshensu (salvianic acid A), were successfully identified as key anti-inflammatory compounds by LC-MS/MS and metabolomics analyses. This is the first study identifying anti-inflammatory compounds in A. arguta (Actinidia arguta) leaves through bioassay-guided fractionation and metabolomics screening. Results of this study would be useful for the application of A. arguta leaves as a nutraceutical. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Metabolomic Screening of Anti-Inflammatory Compounds from the Leaves of Actinidia arguta (Hardy Kiwi) | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/foods8020047 | - |
dc.identifier.bibliographicCitation | FOODS, v.8, no.2 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000460741900007 | - |
dc.identifier.scopusid | 2-s2.0-85063214600 | - |
dc.citation.number | 2 | - |
dc.citation.title | FOODS | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Actinidia arguta | - |
dc.subject.keywordAuthor | caffeic acid derivatives | - |
dc.subject.keywordAuthor | metabolomic screening | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | DANSHENSU | - |
dc.subject.keywordPlus | ESTER | - |
dc.subject.keywordPlus | BUDS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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