The effects of MS-10 dietary supplement, mixture of Korean thistle and thyme extracts, on bone health, and symptoms in menopausal women
- Authors
- Noh, Yoo-Hun; Cheon, Seungui; Kim, In Hye; Lee, Seungah; Yin, XingFu; Jeong, JaeHun; Lee, Hongyeol; Ahn, Jae Hyung; Han, Seung Su; Bae, Yoojung; Jung, Yoonhee; Lee, WonBok
- Issue Date
- Jan-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Menopause; Bone health; Korean thistle; Thyme; ALP; Osteocalcin
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.52, pp 680 - 689
- Pages
- 10
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 52
- Start Page
- 680
- End Page
- 689
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18385
- DOI
- 10.1016/j.jff.2018.11.047
- ISSN
- 1756-4646
- Abstract
- In menopausal women, estrogen deficiency closely affects bone health. Previous studies report that MS-10, a combined extract of Cirsium japonicum and Thymus vulgaris, increases the efficiency of estrogen by activating the estrogen receptor. Here, the ability of MS-10 to enhance bone health and quality of life in women with menopausal symptoms was tested. Treatment with MS-10 induced alterations in the gene expression profile related with bone health of SaOS-2 osteoblast-like cells. MS-10 increased alkaline phosphatase (ALP) activity and osteocalcin, and reduced tartrate-resistant acid phosphatase (TRACP) activity in osteoblast-like cells. A clinical study showed that treatment with MS-10 (500 mg/day for 3 months) led to a significant decrease in ALP and osteocalcin levels. Also, women's scores on the Menopause-Specific Quality of Life questionnaire that takes into account vasomotor, psychosocial, physical, and sexual health, improved by 18.8%. In conclusion, the herbal material MS-10 may improve menopausal symptoms, including bone health.
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.