Protective potentials of far-infrared ray against neuropsychotoxic conditions
- Authors
- Sharma, Naveen; Shin, Eun-Joo; Kim, Nam Hun; Cho, Eun-Hee; Jeong, Ji Hoon; Jang, Choon-Gon; Nah, Seung-Yeol; Nabeshima, Toshitaka; Yoneda, Yukio; Cadet, Jean Lud; Kim, Hyoung-Chun
- Issue Date
- Jan-2019
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Far-infrared ray; Glutathione peroxidase-1 gene; Memory impairments; Behavioral sensitization; Methamphetamine
- Citation
- NEUROCHEMISTRY INTERNATIONAL, v.122, pp 144 - 148
- Pages
- 5
- Journal Title
- NEUROCHEMISTRY INTERNATIONAL
- Volume
- 122
- Start Page
- 144
- End Page
- 148
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18394
- DOI
- 10.1016/j.neuint.2018.11.019
- ISSN
- 0197-0186
1872-9754
- Abstract
- Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the underlying mechanism conveyed by FIR remains unclear. Recently, we demonstrated that exposure to FIR induces antioxidant potentials via up-regulation of glutathione peroxidase (GPx)-1 gene. The antioxidant potentials might be important for the modulation on the neuropsychotoxic conditions. Exposure to FIR protects from methamphetamine (MA)-induced memory impairments via phosphorylation of ERK 1/2 signaling by positive modulation of protein kinase C delta (PKC delta), M1 muscarinic acetylcholine receptor (M1 mAChR), and nuclear factor E2-related factor 2 (Nrf2) transcription factor. In addition, exposure to FIR positively modulates MA-induced behavioral sensitization via attenuating mitochondrial dysfunction by down-regulation of dopamine D1 receptor. In this mini-review, we have discussed with the protective potentials mediated by FIR against MA-induced psychotoxic burdens.
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