Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal
- Authors
- Lee, Min Kyung; Clay, Nicholas E.; Ko, Eunkyung; Smith, Cartney E.; Chen, Lin; Cho, Nicholas; Sung, Hak-Joon; DiPietro, Luisa; Lee, Jonghwi; Kong, Hyunjoon
- Issue Date
- Dec-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- LANGMUIR, v.34, no.50, pp 15276 - 15282
- Pages
- 7
- Journal Title
- LANGMUIR
- Volume
- 34
- Number
- 50
- Start Page
- 15276
- End Page
- 15282
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18629
- DOI
- 10.1021/acs.langmuir.8b01477
- ISSN
- 0743-7463
1520-5827
- Abstract
- Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T-2-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic-co-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 mu m diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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