Integrative functional genomic analysis of human brain development and neuropsychiatric risks
DC Field | Value | Language |
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dc.contributor.author | Li, Mingfeng | - |
dc.contributor.author | Santpere, Gabriel | - |
dc.contributor.author | Kawasawa, Yuka Imamura | - |
dc.contributor.author | Evgrafov, Oleg V. | - |
dc.contributor.author | Gulden, Forrest O. | - |
dc.contributor.author | Pochareddy, Sirisha | - |
dc.contributor.author | Sunkin, Susan M. | - |
dc.contributor.author | Li, Zhen | - |
dc.contributor.author | Shin, Yurae | - |
dc.contributor.author | Zhu, Ying | - |
dc.contributor.author | Sousa, Andre M. M. | - |
dc.contributor.author | Werling, Donna M. | - |
dc.contributor.author | Kitchen, Robert R. | - |
dc.contributor.author | Kang, Hyo Jung | - |
dc.contributor.author | Pletikos, Mihovil | - |
dc.contributor.author | Choi, Jinmyung | - |
dc.contributor.author | Muchnik, Sydney | - |
dc.contributor.author | Xu, Xuming | - |
dc.contributor.author | Wang, Daifeng | - |
dc.contributor.author | Lorente-Galdos, Belen | - |
dc.contributor.author | Liu, Shuang | - |
dc.contributor.author | Giusti-Rodriguez, Paola | - |
dc.contributor.author | Won, Hyejung | - |
dc.contributor.author | de Leeuw, Christiaan A. | - |
dc.contributor.author | Pardinas, Antonio F. | - |
dc.contributor.author | Hu, Ming | - |
dc.contributor.author | Jin, Fulai | - |
dc.contributor.author | Li, Yun | - |
dc.contributor.author | Owen, Michael J. | - |
dc.contributor.author | O'Donovan, Michael C. | - |
dc.contributor.author | Walters, James T. R. | - |
dc.contributor.author | Posthuma, Danielle | - |
dc.contributor.author | Levitt, Pat | - |
dc.contributor.author | Weinberger, Daniel R. | - |
dc.contributor.author | Hyde, Thomas M. | - |
dc.contributor.author | Kleinman, Joel E. | - |
dc.contributor.author | Geschwind, Daniel H. | - |
dc.contributor.author | Hawrylycz, Michael J. | - |
dc.contributor.author | State, Matthew W. | - |
dc.contributor.author | Sanders, Stephan J. | - |
dc.contributor.author | Sullivan, Patrick F. | - |
dc.contributor.author | Gerstein, Mark B. | - |
dc.contributor.author | Lein, Ed S. | - |
dc.contributor.author | Knowles, James A. | - |
dc.contributor.author | Sestan, Nenad | - |
dc.date.available | 2019-05-28T03:37:12Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.issn | 1095-9203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18631 | - |
dc.description.abstract | To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Integrative functional genomic analysis of human brain development and neuropsychiatric risks | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/science.aat7615 | - |
dc.identifier.bibliographicCitation | SCIENCE, v.362, no.6420, pp 1264 - + | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000452994400041 | - |
dc.identifier.scopusid | 2-s2.0-85058377382 | - |
dc.citation.endPage | + | - |
dc.citation.number | 6420 | - |
dc.citation.startPage | 1264 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 362 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | SINGLE-CELL ANALYSIS | - |
dc.subject.keywordPlus | DE-NOVO MUTATIONS | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | EXPRESSION ANALYSIS | - |
dc.subject.keywordPlus | MENTAL-RETARDATION | - |
dc.subject.keywordPlus | READ ALIGNMENT | - |
dc.subject.keywordPlus | TRANSCRIPTOME | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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