Integrative functional genomic analysis of human brain development and neuropsychiatric risksopen access
- Authors
- Li, Mingfeng; Santpere, Gabriel; Kawasawa, Yuka Imamura; Evgrafov, Oleg V.; Gulden, Forrest O.; Pochareddy, Sirisha; Sunkin, Susan M.; Li, Zhen; Shin, Yurae; Zhu, Ying; Sousa, Andre M. M.; Werling, Donna M.; Kitchen, Robert R.; Kang, Hyo Jung; Pletikos, Mihovil; Choi, Jinmyung; Muchnik, Sydney; Xu, Xuming; Wang, Daifeng; Lorente-Galdos, Belen; Liu, Shuang; Giusti-Rodriguez, Paola; Won, Hyejung; de Leeuw, Christiaan A.; Pardinas, Antonio F.; Hu, Ming; Jin, Fulai; Li, Yun; Owen, Michael J.; O'Donovan, Michael C.; Walters, James T. R.; Posthuma, Danielle; Levitt, Pat; Weinberger, Daniel R.; Hyde, Thomas M.; Kleinman, Joel E.; Geschwind, Daniel H.; Hawrylycz, Michael J.; State, Matthew W.; Sanders, Stephan J.; Sullivan, Patrick F.; Gerstein, Mark B.; Lein, Ed S.; Knowles, James A.; Sestan, Nenad
- Issue Date
- Dec-2018
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE, v.362, no.6420, pp 1264 - +
- Journal Title
- SCIENCE
- Volume
- 362
- Number
- 6420
- Start Page
- 1264
- End Page
- +
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18631
- DOI
- 10.1126/science.aat7615
- ISSN
- 0036-8075
1095-9203
- Abstract
- To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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