Development of a novel celecoxib-loaded nanosuspension using a wet media milling process
- Authors
- Jeong, Sung Chan; Kim, Dong Shik; Jin, Sung Giu; Youn, Yu Seok; Oh, Kyung Taek; Li, Dong Xun; Yong, Chul Soon; Kim, Jong Oh; Kim, Kyeong Soo; Choi, Han-Gon
- Issue Date
- Sep-2018
- Publisher
- GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
- Citation
- PHARMAZIE, v.73, no.9, pp 498 - 502
- Pages
- 5
- Journal Title
- PHARMAZIE
- Volume
- 73
- Number
- 9
- Start Page
- 498
- End Page
- 502
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18685
- DOI
- 10.1691/ph.2018.8035
- ISSN
- 0031-7144
- Abstract
- To develop a novel celecoxib (CXB)-loaded drug delivery system, numerous nanosuspensions were prepared with various polymers and surfactants using a wet media milling process, and their particle sizes were subsequently determined. A 2(4) full factorial design was used to identify the most appropriate preparation conditions. Pharmacokinetics of the selected nanosuspension were performed in rats and compared with those of a drug powder and a commercial CXB-loaded product. Among the carriers investigated, copovidone and sodium lauryl sulphate gave the smallest particle size of the drug in the nanosuspension. In particular, the nanosuspension prepared with 5% CXB, 4% copovidone, and 0.1% sodium lauryl sulphate, under the appropriate conditions, showed a particle size of approximately 190 nm, which was physically stable for at least 8 weeks. This nanosuspension provided a significantly higher plasma concentration and AUC in rats as compared with the drug powder and the commercial product. Thus, this novel CXB-loaded nanosuspension is a promising candidate with excellent stability and enhanced oral bioavailability.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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