Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder canceropen access
- Authors
- Shim, U.J.; Lee, I.-S.; Kang, H.W.; Kim, J.; Kim, W.T.; Kim, I.Y.; Ryu, K.H.; Choi, Y.H.; Moon, S.-K.; Kim, Y.-J.; Yun, S.-J.; Lee, S.-C.; Kim, W.-J.
- Issue Date
- Sep-2013
- Publisher
- 대한비뇨의학회
- Keywords
- Bladder cancer; Human DBC1 protein; Prognosis
- Citation
- Korean Journal of Urology, v.54, no.9, pp 631 - 637
- Pages
- 7
- Journal Title
- Korean Journal of Urology
- Volume
- 54
- Number
- 9
- Start Page
- 631
- End Page
- 637
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19892
- DOI
- 10.4111/kju.2013.54.9.631
- ISSN
- 2005-6737
2466-054X
- Abstract
- Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC. © The Korean Urological Association, 2013.
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