Validation of a Scoring System for Predicting Malignancy in Patients Diagnosed with Atypical Ductal Hyperplasia Using an Ultrasound-Guided Core Needle Biopsy
- Authors
- Kim, Jisun; Han, Wonshik; Go, Eun-Young; Moon, Hyeong-Gon; Ahn, Soo Kyung; Shin, Hee-Chul; You, Jee-Man; Chang, Jung Min; Cho, Nariya; Moon, Woo Kyung; Park, In Ae; Noh, Dong-Young
- Issue Date
- Dec-2012
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast hyperplasia; Breast neoplasms; Diagnostic errors; Needle biopsy
- Citation
- JOURNAL OF BREAST CANCER, v.15, no.4, pp 407 - 411
- Pages
- 5
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 15
- Number
- 4
- Start Page
- 407
- End Page
- 411
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20005
- DOI
- 10.4048/jbc.2012.15.4.407
- ISSN
- 1738-6756
2092-9900
- Abstract
- Purpose: The need for surgical excision in patients with ultrasound-guided core needle biopsy (CNB)-diagnosed atypical ductal hyperplasia (ADH) remains an issue of debate. The present study sought to validate a scoring system (the U score, for underestimation) that we have previously developed for predicting malignancy in CNB-diagnosed ADH. Methods: The study prospectively enrolled 85 female patients with CNB-diagnosed ADH who underwent subsequent surgical excision. Underestimation was defined as a surgical specimen having malignant foci. Results: The overall underestimation rate was 37% (31/85). Multivariate analysis showed that a clinically palpable mass, microcalcification on imaging, size >15 mm and a patient age of >= 50 years were independently associated with underestimation. When applied to the scoring system, the validation score was significant (p<0.001; area under the curve, 0.852). No patient with a U score <3.5 had an underestimated lesion. Conclusion: The present study successfully validated the efficacy of our scoring system for predicting malignancy in CNB-diagnosed ADH. A U score of <= 3.5 indicates that surgical excision may not be necessary.
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