A Novel Antibacterial Compound from Siegesbeckia glabrescens
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Soo | - |
dc.contributor.author | Kim, Hyungil | - |
dc.contributor.author | Jung, Eunsun | - |
dc.contributor.author | Kim, Jang-Hyun | - |
dc.contributor.author | Hwang, Wangtaek | - |
dc.contributor.author | Kang, Eun-Ju | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Ha, Byung-Jo | - |
dc.contributor.author | Lee, Jongsung | - |
dc.contributor.author | Park, Deokhoon | - |
dc.date.available | 2019-05-29T05:35:58Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20067 | - |
dc.description.abstract | The crude methanol extract of the dried aerial parts of Siegesbeckia glabrescens (Compositae) showed antibacterial activity against the foodborne pathogen Staphylococcus aureus. Bioactivity-guided separation led to the isolation of 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid from nature for the first time. The structure was determined by spectroscopic data analysis (UV, MS, and NMR). The minimal inhibitory concentration (MIC) of 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid against S. aureus was found to be 3.12 mu g/mL. In addition, in a further antimicrobial activity assay against Gram-positive (B. subtilis, E. faecalis, P. acnes, S. epidermidis, S. schleiferi subsp. coagulans, S. agalactiae and S. pyrogens), and Gram-negative bacteria (E. coli and P. aeruginosa), and yeast strains (C. alibicans and F. neoformans), the antimicrobial activity of the compound was found to be specific for Gram-positive bacteria. The MIC values of the compound for Gram-positive bacteria ranged from 3.12 to 25 mu g/mL. Furthermore, it was found that the 2-(isobutyryloxy)-4-methylpentanoic acid substituent may operate as a key factor in the antibacterial activity of the compound, together with the laurate group. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | A Novel Antibacterial Compound from Siegesbeckia glabrescens | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/molecules171112469 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.17, no.11, pp 12469 - 12477 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000311428400001 | - |
dc.identifier.scopusid | 2-s2.0-84870201083 | - |
dc.citation.endPage | 12477 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 12469 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | antibacterial activity | - |
dc.subject.keywordAuthor | 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid | - |
dc.subject.keywordAuthor | lauric acid | - |
dc.subject.keywordAuthor | Siegesbeckia glabrescens | - |
dc.subject.keywordPlus | RESISTANT STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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