A Novel Antibacterial Compound from Siegesbeckia glabrescens
- Authors
- Kim, Young-Soo; Kim, Hyungil; Jung, Eunsun; Kim, Jang-Hyun; Hwang, Wangtaek; Kang, Eun-Ju; Lee, Sanghyun; Ha, Byung-Jo; Lee, Jongsung; Park, Deokhoon
- Issue Date
- Nov-2012
- Publisher
- MDPI AG
- Keywords
- antibacterial activity; 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid; lauric acid; Siegesbeckia glabrescens
- Citation
- MOLECULES, v.17, no.11, pp 12469 - 12477
- Pages
- 9
- Journal Title
- MOLECULES
- Volume
- 17
- Number
- 11
- Start Page
- 12469
- End Page
- 12477
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20067
- DOI
- 10.3390/molecules171112469
- ISSN
- 1420-3049
- Abstract
- The crude methanol extract of the dried aerial parts of Siegesbeckia glabrescens (Compositae) showed antibacterial activity against the foodborne pathogen Staphylococcus aureus. Bioactivity-guided separation led to the isolation of 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid from nature for the first time. The structure was determined by spectroscopic data analysis (UV, MS, and NMR). The minimal inhibitory concentration (MIC) of 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid against S. aureus was found to be 3.12 mu g/mL. In addition, in a further antimicrobial activity assay against Gram-positive (B. subtilis, E. faecalis, P. acnes, S. epidermidis, S. schleiferi subsp. coagulans, S. agalactiae and S. pyrogens), and Gram-negative bacteria (E. coli and P. aeruginosa), and yeast strains (C. alibicans and F. neoformans), the antimicrobial activity of the compound was found to be specific for Gram-positive bacteria. The MIC values of the compound for Gram-positive bacteria ranged from 3.12 to 25 mu g/mL. Furthermore, it was found that the 2-(isobutyryloxy)-4-methylpentanoic acid substituent may operate as a key factor in the antibacterial activity of the compound, together with the laurate group.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20067)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.