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The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
- Authors
- Choe, Kang In; Kwon, Joo Hee; Park, Kwan Hee; Oh, Myeong Hwan; Kim, Manh Heun; Kim, Han Hyuk; Cho, Su Hyun; Chung, Eun Kyung; Ha, Sung Yi; Lee, Min Won
- Issue Date
- Oct-2012
- Publisher
- MDPI
- Keywords
- Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC
- Citation
- MOLECULES, v.17, no.10, pp 11484 - 11494
- Pages
- 11
- Journal Title
- MOLECULES
- Volume
- 17
- Number
- 10
- Start Page
- 11484
- End Page
- 11494
- ISSN
- 1420-3049
- Abstract
- Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-beta-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
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