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PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation

Authors
Jeong, Hyo-SoonPark, Kyoung-ChanKim, Dong-Seok
Issue Date
Aug-2012
Publisher
SPRINGER
Keywords
ERK; Melanocytes; DUSP6; PP2A; Sphingosylphosphorylcholine
Citation
MOLECULAR AND CELLULAR BIOCHEMISTRY, v.367, no.1-2, pp 43 - 49
Pages
7
Journal Title
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume
367
Number
1-2
Start Page
43
End Page
49
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20176
DOI
10.1007/s11010-012-1317-8
ISSN
0300-8177
1573-4919
Abstract
Activation of extracellular signal-related kinase (ERK) is involved in decreased melanogenesis by sphingosylphosphorylcholine (SPC). In the present study, we confirmed that SPC activated ERK and that a specific inhibitor of the ERK pathway (PD98059) recovered SPC-induced hypopigmentation. Moreover, we found that SPC significantly reduces protein phosphatase 2A (PP2A) activity in Mel-Ab cells, and that PP2A activator treatment abrogated SPC-induced hypopigmentation. We determined that alpha-melanocyte-stimulating hormone (alpha-MSH) increased the expression of dual-specificity phosphatase 6 (DUSP6), an ERK phosphatase, in a time-dependent manner. In contrast, SPC decreased the level of DUSP6 in Mel-Ab cells. Furthermore, inhibiting DUSP6 increased ERK activation and subsequently augmented the SPC-induced hypopigmenting effects. Taken together, our data suggest that SPC-induced phosphatase inhibition is also responsible for the hypopigmentary effects.
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