Visible light-induced photocurable (forming a film) low molecular weight chitosan derivatives for biomedical applications: Synthesis, characterization and in vitro biocompatibility
- Authors
- Seo, Si Yoong; Park, Shin Hye; Lee, Hyung Jae; Na, Ha Na; Kim, Kwang Il; Han, Dong Keun; Lee, Jae Kwan; Ito, Yoshihiro; Son, Tae Il
- Issue Date
- Jul-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Chitosan; Low molecular weight chitosan; Furfuryl glycidyl ether; Photocurable polymers
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.18, no.4, pp 1258 - 1262
- Pages
- 5
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 18
- Number
- 4
- Start Page
- 1258
- End Page
- 1262
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20182
- DOI
- 10.1016/j.jiec.2012.01.006
- ISSN
- 1226-086X
1876-794X
- Abstract
- In this work, visible light-induced photocurable low molecular weight chitosan derivatives (F-LMC: furfuryl-low molecular weight chitosan) were prepared by nitrous acid decomposition followed by modification with furfuryl glycidyl ether. The structure of the decomposition products (LMC: low molecular weight chitosan) was characterized by FT-IR analysis. The structure and molecular weight of F-LMC, prepared from the decomposition products by modification with furfuryl glycidyl ether, were characterized by H-1 NMR and GPC analysis, respectively. F-LMC was initially water-soluble, but after the exposure to visible light, it became water-insoluble, indicating that F-LMC undergoes visible light-induced inter- and intra-molecular cross-linking. The cross-linking was determined by concentration of F-LMC and time of exposure to visible light. The cytotoxicity test using fibroblast 3T3 showed no toxicity of F-LMC. Cross-linked F-LMC surface inhibited cell adherence. (c) 2012 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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