Construction of healthy arteries using computed tomography and virtual histology intravascular ultrasound
- Authors
- Ryou, Hong Sun; Kim, Seungwook; Kim, Sang Wook; Cho, Seong Wook
- Issue Date
- Jun-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Healthy artery; Hemodynamics; Virtual histology intravascular ultrasound; Computational fluid dynamics; Coronary artery
- Citation
- JOURNAL OF BIOMECHANICS, v.45, no.9, pp 1612 - 1618
- Pages
- 7
- Journal Title
- JOURNAL OF BIOMECHANICS
- Volume
- 45
- Number
- 9
- Start Page
- 1612
- End Page
- 1618
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20251
- DOI
- 10.1016/j.jbiomech.2012.04.003
- ISSN
- 0021-9290
1873-2380
- Abstract
- Vessel geometry for numerical analysis is generally obtained by computed tomography (CT) or magnetic resonance imaging (MRI) and intravascular ultrasound (IVUS). Most medical imaging is obtained from patients for hemodynamic analysis due to the properties of vascular disease and the difficulties in angiography. To predict the site where plaque occurs and understand the progression of the lesion, however, it is necessary to take into consideration not only the diseased artery, but also the blood flow characteristics of healthy artery. In order to simulate healthy vessels prior to lesion formation, we performed CT and virtual histology intravascular ultrasound (VH-IVUS) on three actual patients and this data was used to develop criteria for healthy vessel construction, a method that virtually removes all intravascular plaque. The lumen of a vessel generated by CT and the lumen from VH-IVUS were compared, and the cross-sectional areas of plaque components (fibrous, fibrofatty, dense calcium, and necrotic) and the lumen from VH-IVUS were analyzed. Geometric differences in the healthy vessel and diseased vessel were analyzed, and flow characteristics of the healthy vessel and diseased vessel were compared through computational fluid dynamics simulation. Low average wall shear stress (AWSS) was distributed in the site where plaque was removed from the healthy vessel, and a high oscillatory shear index (OSI) was observed in the region proximal to the site where plaque previously existed. Low AWSS and high OSI are widely accepted indicators of plaque formation or the direction of plaque progression. A numerical model that effectively predicts lesion forming sites was also generated based on the, healthy vessel construction method presented in this study. (C) 2012 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Mechanical Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20251)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.