Hypopigmentary effects of 4-n-butylresorcinol and resveratrol in combination
- Authors
- Kim, Su Yeon; Park, Kyoung-Chan; Kwon, Sun-Bang; Kim, Dong-Seok
- Issue Date
- Jun-2012
- Publisher
- GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
- Citation
- PHARMAZIE, v.67, no.6, pp 542 - 546
- Pages
- 5
- Journal Title
- PHARMAZIE
- Volume
- 67
- Number
- 6
- Start Page
- 542
- End Page
- 546
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20295
- DOI
- 10.1691/ph.2012.1660
- ISSN
- 0031-7144
- Abstract
- In the present study, the effects of 4-n-butylresorcinol and/or resveratrol on melanogenesis were studied. To achieve synergistic effects and avoid potential adverse effects, combinations of the agents in low concentrations were investigated. Our results show that 1 mu M of 4-n-butylresorcinol and 1 mu M of resveratrol did not individually inhibit melanin synthesis. However, the combination of 4-n-butylresorcinol (1 mu M) and resveratrol (1 mu M) significantly reduced melanin synthesis. Furthermore, 4-n-butylresorcinol (10 mu M) and resveratrol (10 mu M) decreased melanogenesis much stronger. 4-n-Butylresorcinol is reported to directly inhibit tyrosinase, the rate-limiting melanogenic enzyme, without changing tyrosinase levels. Our results also showed that resveratrol did not directly inhibit tyrosinase at 0.1-10 mu M. Literature has reported that resveratrol led to post-transcriptional regulation of tyrosinase. However, Western blot analysis showed that neither 4-n-butylresorcinol nor resveratrol alone decreased tyrosinase protein levels. Surprisingly, the combination of 4-n-butylresorcinol and resveratrol reduced tyrosinase levels. Therefore, these results indicate that the synergistic hypopigmentary effect of 4-n-butylresorcinol and resveratrol results from a decreased level of tyrosinase possibly resulting from synergistic action of 4-n-butylresorcinol on tyrosinase alteration by resveratrol.
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