Development of Estimation Methods of Skin Oxidation and Evaluation of Anti-Oxidative Effects of Genistein in Topical Formulations
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Na, Yeon Joo | - |
dc.contributor.author | Kim, Dongju | - |
dc.contributor.author | Kim, Yeongseok | - |
dc.contributor.author | Kim, Hyeong Min | - |
dc.contributor.author | Hwang, Sung-Ha | - |
dc.contributor.author | Kwak, Jiyeon | - |
dc.contributor.author | Kuh, Hyo-Jeong | - |
dc.contributor.author | Lee, Jaehwi | - |
dc.date.available | 2019-05-29T07:34:12Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20302 | - |
dc.description.abstract | The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion (Fe3+) and xylenol orange, often called FOX assay and subsequent monitoring of absorbance values of the reactant at 540 nm. The reaction was to some extent pH-dependent and detection sensitivity was greatest at pH 1.75. Genistein liposomal gel demonstrated better anti-oxidative effect with regard to lowering hydrogen peroxide levels elevated by UVB irradiation compared to genistein-suspended gel. A linear relationship has been observed between anti-oxidative effect of genistein and drug deposition in the skin tissue. Genistein liposomal gel resulting in the localization of the drug in the deeper skin led to improved anti-oxidative effect compared to genistein gel. The suggested method for evaluation of oxidation of the skin can be used as a tool to screen effective anti-oxidative agents and their delivery systems acting on the skin. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Development of Estimation Methods of Skin Oxidation and Evaluation of Anti-Oxidative Effects of Genistein in Topical Formulations | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2012.16.3.205 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.16, no.3, pp 205 - 209 | - |
dc.identifier.kciid | ART001668738 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000306155600009 | - |
dc.identifier.scopusid | 2-s2.0-84864001781 | - |
dc.citation.endPage | 209 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 205 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Oxidation | - |
dc.subject.keywordAuthor | Skin | - |
dc.subject.keywordAuthor | Hydrogen peroxide | - |
dc.subject.keywordAuthor | Genistein | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | ISOFLAVONES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | ASSAY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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