Levels of Plasma-soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Are Correlated with Disease Activity in Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Choi, Sang Tae | - |
dc.contributor.author | Kang, Eun-Jin | - |
dc.contributor.author | Ha, You Jung | - |
dc.contributor.author | Song, Jung-Soo | - |
dc.date.available | 2019-05-29T07:35:45Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.issn | 1499-2752 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20351 | - |
dc.description.abstract | Objective. To determine whether levels of plasma-soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are elevated in patients with rheumatoid arthritis (RA) and whether levels are correlated with disease activity and other variables. Methods. Our study included 71 patients with RA and 50 age- and sex-matched healthy controls. Clinical characteristics and laboratory measures, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and 28-joint Disease Activity Score (DAS28) were assessed. Plasma levels of sTREM-1 and tumor necrosis factor-alpha (TNF-alpha) were measured by ELISA. Results. Patients with RA had significantly higher plasma sTREM-1 levels than healthy controls (170.10 +/- 84.71 pg/ml vs 97.41 +/- 40.64 pg/ml; p < 0.001). In patients with RA, plasma sTREM-1 levels were found to be correlated with DAS28, ESR, CRP, white blood cell counts, neutrophil counts, and plasma TNF-alpha levels (r = 0.329, p = 0.005; r = 0.241, p = 0.043; r = 0.314, p < 0.001; r = 0.261, p = 0.028; r = 0.278, p = 0.019; and r = 0.313, p = 0.009, respectively). Plasma sTREM-1 levels in patients with active disease status (DAS28 > 3.2) were significantly higher than in those with low disease status (DAS28 <= 3.2; 208.89 +/- 100.14 pg/ml vs 150.29 +/- 68.70 pg/ml; p = 0.005). Conclusion. Patients with RA had higher plasma sTREM-1 levels than healthy controls, and plasma sTREM-1 levels were correlated with disease activity measures, suggesting that plasma sTREM-1 could play a role in the inflammatory process associated with TNF-alpha, and that it may be a useful disease activity marker in RA. (First Release March 15 2012; J Rheumatol 2012;39:933-8; doi:10.3899/jrheum.111218) | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.title | Levels of Plasma-soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Are Correlated with Disease Activity in Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3899/jrheum.111218 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.39, no.5, pp 933 - 938 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000303975300011 | - |
dc.identifier.scopusid | 2-s2.0-84860770234 | - |
dc.citation.endPage | 938 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 933 | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 39 | - |
dc.type.docType | Article | - |
dc.publisher.location | 캐나다 | - |
dc.subject.keywordAuthor | TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 | - |
dc.subject.keywordAuthor | RHEUMATOID ARTHRITIS | - |
dc.subject.keywordAuthor | DISEASE ACTIVITY | - |
dc.subject.keywordPlus | TREM-1 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | MEDIATOR | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | MONOCYTES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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