Levels of Plasma-soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Are Correlated with Disease Activity in Rheumatoid Arthritis
- Authors
- Choi, Sang Tae; Kang, Eun-Jin; Ha, You Jung; Song, Jung-Soo
- Issue Date
- May-2012
- Publisher
- J RHEUMATOL PUBL CO
- Keywords
- TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1; RHEUMATOID ARTHRITIS; DISEASE ACTIVITY
- Citation
- JOURNAL OF RHEUMATOLOGY, v.39, no.5, pp 933 - 938
- Pages
- 6
- Journal Title
- JOURNAL OF RHEUMATOLOGY
- Volume
- 39
- Number
- 5
- Start Page
- 933
- End Page
- 938
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20351
- DOI
- 10.3899/jrheum.111218
- ISSN
- 0315-162X
1499-2752
- Abstract
- Objective. To determine whether levels of plasma-soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are elevated in patients with rheumatoid arthritis (RA) and whether levels are correlated with disease activity and other variables. Methods. Our study included 71 patients with RA and 50 age- and sex-matched healthy controls. Clinical characteristics and laboratory measures, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and 28-joint Disease Activity Score (DAS28) were assessed. Plasma levels of sTREM-1 and tumor necrosis factor-alpha (TNF-alpha) were measured by ELISA. Results. Patients with RA had significantly higher plasma sTREM-1 levels than healthy controls (170.10 +/- 84.71 pg/ml vs 97.41 +/- 40.64 pg/ml; p < 0.001). In patients with RA, plasma sTREM-1 levels were found to be correlated with DAS28, ESR, CRP, white blood cell counts, neutrophil counts, and plasma TNF-alpha levels (r = 0.329, p = 0.005; r = 0.241, p = 0.043; r = 0.314, p < 0.001; r = 0.261, p = 0.028; r = 0.278, p = 0.019; and r = 0.313, p = 0.009, respectively). Plasma sTREM-1 levels in patients with active disease status (DAS28 > 3.2) were significantly higher than in those with low disease status (DAS28 <= 3.2; 208.89 +/- 100.14 pg/ml vs 150.29 +/- 68.70 pg/ml; p = 0.005). Conclusion. Patients with RA had higher plasma sTREM-1 levels than healthy controls, and plasma sTREM-1 levels were correlated with disease activity measures, suggesting that plasma sTREM-1 could play a role in the inflammatory process associated with TNF-alpha, and that it may be a useful disease activity marker in RA. (First Release March 15 2012; J Rheumatol 2012;39:933-8; doi:10.3899/jrheum.111218)
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