Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice
DC Field | Value | Language |
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dc.contributor.author | Won, Tae Joon | - |
dc.contributor.author | Kim, Bongjoon | - |
dc.contributor.author | Lee, Yunjung | - |
dc.contributor.author | Bang, Joon Seok | - |
dc.contributor.author | Oh, Eun Seul | - |
dc.contributor.author | Yoo, Jong-Sun | - |
dc.contributor.author | Hyung, Kyeong Eun | - |
dc.contributor.author | Yoon, Joowon | - |
dc.contributor.author | Hwang, Sehee | - |
dc.contributor.author | Park, Eon Sub | - |
dc.contributor.author | Park, So-Young | - |
dc.contributor.author | Hwang, Kwang Woo | - |
dc.date.available | 2019-05-29T07:36:18Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.issn | 1090-2163 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20369 | - |
dc.description.abstract | Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-gamma in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-gamma, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-gamma and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-gamma. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cellimm.2012.05.013 | - |
dc.identifier.bibliographicCitation | CELLULAR IMMUNOLOGY, v.277, no.1-2, pp 49 - 57 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000307528300007 | - |
dc.identifier.scopusid | 2-s2.0-84864294841 | - |
dc.citation.endPage | 57 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 49 | - |
dc.citation.title | CELLULAR IMMUNOLOGY | - |
dc.citation.volume | 277 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Kimchi | - |
dc.subject.keywordAuthor | Lactobacillus plantarum CJLP133 | - |
dc.subject.keywordAuthor | NC/Nga mouse | - |
dc.subject.keywordAuthor | House-dust mite | - |
dc.subject.keywordAuthor | Type 1 helper T cells | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
dc.subject.keywordAuthor | Axillary lymph node | - |
dc.subject.keywordPlus | LACTIC-ACID BACTERIA | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | SKIN-LESIONS | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | TOPICAL APPLICATION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | STRAINS | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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