Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice
- Authors
- Won, Tae Joon; Kim, Bongjoon; Lee, Yunjung; Bang, Joon Seok; Oh, Eun Seul; Yoo, Jong-Sun; Hyung, Kyeong Eun; Yoon, Joowon; Hwang, Sehee; Park, Eon Sub; Park, So-Young; Hwang, Kwang Woo
- Issue Date
- May-2012
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Atopic dermatitis; Kimchi; Lactobacillus plantarum CJLP133; NC/Nga mouse; House-dust mite; Type 1 helper T cells; Regulatory T cells; Axillary lymph node
- Citation
- CELLULAR IMMUNOLOGY, v.277, no.1-2, pp 49 - 57
- Pages
- 9
- Journal Title
- CELLULAR IMMUNOLOGY
- Volume
- 277
- Number
- 1-2
- Start Page
- 49
- End Page
- 57
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20369
- DOI
- 10.1016/j.cellimm.2012.05.013
- ISSN
- 0008-8749
1090-2163
- Abstract
- Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-gamma in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-gamma, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-gamma and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-gamma. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis. (C) 2012 Elsevier Inc. All rights reserved.
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