Inactivation of the MSLNL gene encoding mesothelin-like protein during African great ape evolution
- Authors
- Kim, Dong-Wook; Jeong, Sangkyun; Kim, Dong Seon; Kim, Heui-Soo; Seo, Sang-Beom; Hahn, Yoonsoo
- Issue Date
- Mar-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Gene inactivation; Human evolution; Mesothelin-like; MSLNL; Nonsense mutation
- Citation
- GENE, v.496, no.1, pp 17 - 21
- Pages
- 5
- Journal Title
- GENE
- Volume
- 496
- Number
- 1
- Start Page
- 17
- End Page
- 21
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20443
- DOI
- 10.1016/j.gene.2012.01.005
- ISSN
- 0378-1119
1879-0038
- Abstract
- Loss of gene function is implicated in the emergence of novel phenotypes during organism evolution. Here, we report the inactivation of the MSLNL gene encoding mesothelin-like protein in African great ape evolution. Human MSLNL has a nonsense mutation in exon 10 and two polymorphic mutations: a frameshift in exon 3 and a nonsense codon in exon 8. The gorilla gene also shows multiple deleterious mutations, including a premature stop codon, a deletion, and a splice site mutation. Molecular evolutionary analysis indicated relaxed selection pressure on MSLNL in African great ape lineages, which suggested that MSLNL might have become inactivated before the divergence of human, chimpanzee and gorilla. The mouse Mslnl gene is highly expressed in olfactory epithelium and moderately expressed in several other tissues. We propose that the loss of MSLNL may be associated with the evolution of the olfactory system in African great apes including human. (C) 2012 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20443)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.