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Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum
- Authors
- Shin, Hyun Jung; Lee, So Young; Kim, Ju Sun; Lee, Sanghyun; Choi, Ran Joo; Chung, Ha Sook; Kim, Yeong Shik; Kang, Sam Sik
- Issue Date
- Mar-2012
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Dendranthema zawadskii var. latilobum; Asteraceae; germacranolide; eudesmane glucoside; nitric oxide inhibition
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.60, no.3, pp 306 - 314
- Pages
- 9
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 60
- Number
- 3
- Start Page
- 306
- End Page
- 314
- ISSN
- 0009-2363
1347-5223
- Abstract
- Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (-)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 mu m, respectively.
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