Antibacterial Activity of Triterpenoids from Clerodendron trichotomum
- Authors
- Ji Won Choi; 조은주; Dong Gu Lee; 최경; Jajung Ku; Kwang-Woo Park; 이상현
- Issue Date
- Sep-2012
- Publisher
- 한국응용생명화학회
- Keywords
- antibacterial activity; β-amyrin; Clerodendron trichotomum; 22-dehydroclerosterol
- Citation
- Journal of Applied Biological Chemistry, v.55, no.3, pp 169 - 172
- Pages
- 4
- Journal Title
- Journal of Applied Biological Chemistry
- Volume
- 55
- Number
- 3
- Start Page
- 169
- End Page
- 172
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20668
- ISSN
- 1976-0442
2234-7941
- Abstract
- The aim of this research was to investigate the antibacterial activity of Clerodendron trichotomum. Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate,and n-butanol fractions from C. trichotomum were tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori. The n-hexane and MC fractions showed antibacterial activity against H. pylori at a concentration of 1.7 mg/mL and showed inhibition zones of 10 and 11 mm in disc assay, respectively. Further testing of 22-dehydroclerosterol and β-amyrin (each 3.4mg/mL) from the MC fraction of C. trichotomum revealed moderate antibacterial effects against E. coli, S. aureus, and H. pylori. In particular, β-amyrin showed clear zones of 12 and 13mm against E. coli and H. pylori, respectively, suggesting its potential as an antibacterial agent. The active compounds from C. trichotomum might provide a promising therapeutic agent against infections by E. coli, S. aureus, and H. pylori.
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