Determination of three preservatives, cresol, chlorocresol and benzethonium, in drugs by high performance liquid chromatography-ultraviolet (HPLC-UV) detection
DC Field | Value | Language |
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dc.contributor.author | Lee, J. | - |
dc.contributor.author | Shin, S. | - |
dc.contributor.author | Shin, H. | - |
dc.contributor.author | Huh, Y. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Kim, D.-H. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Kim, Y.-O. | - |
dc.contributor.author | Han, S.B. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Park, J.H. | - |
dc.contributor.author | Kwon, S.W. | - |
dc.date.available | 2019-05-29T09:33:13Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20861 | - |
dc.description.abstract | High performance liquid chromatography-ultraviolet (HPLC-UV) detection method was performed to simultaneously determine three preservatives: cresol, chlorocresol and benzethonium. According to the current Korean Pharmacopeia Codex, the only-available analytical method for discerning the three preservatives uses thin-layer chromatography, which does not provide accurate detection or quantification. Therefore, this study focused on developing a new HPLC-UV method which gives fast, accurate and sensitive outcomes. The experiment was done using Phenomenex Gemini column [C18 (250 × 4.6 mm, 5 μm)] and the mobile system was methanol and 0.01 M potassium phosphate (monobasic) in water (pH = 3.3). The developed method was validated through linearity, range, system suitability, precision, accuracy, recovery and inter-laboratory variation. © 2012 The Korean Society of Pharmaceutical Sciences and Technology and Springer Dordrecht. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국약제학회 | - |
dc.title | Determination of three preservatives, cresol, chlorocresol and benzethonium, in drugs by high performance liquid chromatography-ultraviolet (HPLC-UV) detection | - |
dc.title.alternative | Determination of three preservatives, cresol, chlorocresol and benzethonium, in drugs by high performance liquid chromatography–ultraviolet (HPLC–UV) detection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s40005-012-0008-5 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.42, no.1, pp 47 - 50 | - |
dc.identifier.kciid | ART001636219 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84870336561 | - |
dc.citation.endPage | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Benzethonium | - |
dc.subject.keywordAuthor | Chlorocresol | - |
dc.subject.keywordAuthor | Cresol | - |
dc.subject.keywordAuthor | HPLC-UV | - |
dc.subject.keywordAuthor | Preservatives | - |
dc.subject.keywordPlus | benzethonium chloride | - |
dc.subject.keywordPlus | chlorocresol | - |
dc.subject.keywordPlus | cresol | - |
dc.subject.keywordPlus | methanol | - |
dc.subject.keywordPlus | potassium dihydrogen phosphate | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | drug determination | - |
dc.subject.keywordPlus | high performance liquid chromatography | - |
dc.subject.keywordPlus | inter laboratory variation | - |
dc.subject.keywordPlus | linearity | - |
dc.subject.keywordPlus | precision and accuracy | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | range | - |
dc.subject.keywordPlus | recovery | - |
dc.subject.keywordPlus | repeatability | - |
dc.subject.keywordPlus | system suitability | - |
dc.subject.keywordPlus | ultraviolet spectroscopy | - |
dc.subject.keywordPlus | validation process | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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