Protective Effect of Extract from Rumex Aquaticus Herba on Ethanol-induced Gastric Damage in Rats
- Authors
- Kwak, Hyun Soo; Park, Sun Young; Thao Thanh Nguyen; Kim, Chung Hyo; Lee, Jong Mi; Suh, Jung Sook; Whang, Wan Kyunn; Sohn, Uy Dong
- Issue Date
- Nov-2012
- Publisher
- KARGER
- Keywords
- Ethanol; Flavonoids; Gastritis; Antiinflammation; Antioxidant; Quercetin
- Citation
- PHARMACOLOGY, v.90, no.5-6, pp 288 - 297
- Pages
- 10
- Journal Title
- PHARMACOLOGY
- Volume
- 90
- Number
- 5-6
- Start Page
- 288
- End Page
- 297
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20998
- DOI
- 10.1159/000342767
- ISSN
- 0031-7012
1423-0313
- Abstract
- Background/Aims: In this study, we investigated the gastroprotective effect of extract including quercetin-3-O-beta-D-glucuronopyranoside (EIQ) from Rumex aquaticus herba against the ethanol-induced gastric damage in rats. Methods: The rats were divided into eight groups composed of a non-ethanol group, only EIQ (10 mg/kg) group, groups with absolute ethanol after pretreatment with various doses of EIQ (1, 3 and 10 mg/kg), rebamipide (10 mg/kg), stillen (40 mg/kg) and a control receiving only absolute ethanol. Ethanol-induced gastric lesions, lipid peroxidation, neutrophil infiltration and glutathione level were measured. Superoxide dismutase (SOD) and catalase activity were assessed by an assay kit. Protein expression of SOD, catalase or hemoxygenase-1 (HO-1) was assessed by western blotting analysis. Results and Conclusion: In the absolute ethanol treated group, gastric lesion and malondialdehyde levels were significantly increased with enhanced myeloperoxidase activity. Administration of EIQ 1 h prior to ethanol treatment significantly inhibited the formation of gastric lesions and the elevation of the malondialdehyde levels with myeloperoxidase activity. In addition, pretreatment with EIQ significantly increased the level of glutathione, and elevated the activity and protein expression of radical scavenging enzymes, such as SOD, catalase and HO-1. EIQ may exert anti-inflammatory and anti-oxidative effects against ethanol-induced gastric injury through the reduction of lipid peroxidation, myeloperoxidase activity and free radicals. Copyright (C) 2012 S. Karger AG, Basel
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20998)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.