Enhanced protein-mediated binding between oligonucleotide-gold nanoparticle composites and cell surfaces: co-transport of proteins and composites
- Authors
- Kim, Yu Jin; Ryou, Sang-Mi; Kim, Sudeok; Yeom, Ji-Hyun; Han, Min Su; Lee, Kangseok; Seong ,Maeng-Je
- Issue Date
- Dec-2012
- Publisher
- Royal Society of Chemistry
- Citation
- Journal of Materials Chemistry, v.22, no.48, pp 25036 - 25041
- Pages
- 6
- Journal Title
- Journal of Materials Chemistry
- Volume
- 22
- Number
- 48
- Start Page
- 25036
- End Page
- 25041
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21005
- DOI
- 10.1039/c2jm34047j
- ISSN
- 0959-9428
1364-5501
- Abstract
- The measurement of the binding force between a cell membrane and an oligonucleotide-functionalized, gold-coated tip using atomic force microscope force spectroscopy showed enhanced binding forces due to the presence of proteins in the buffer. The cellular uptake of oligonucleotide-gold nanoparticle composites was also enhanced when the composites were coated with serum proteins. Confocal microscopy image analysis of fluorescently labeled serum proteins and the oligonucleotides of the composites revealed co-transport of proteins and the composites.
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- Appears in
Collections - College of Natural Sciences > Department of Physics > 1. Journal Articles
- College of Natural Sciences > Department of Life Science > 1. Journal Articles
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