Xenoestrogenic chemicals effectively alter sperm functional behavior in mice
- Authors
- Park, Yoo-Jin; Mohamed, El-Sayed A.; Kwon, Woo-Sung; You, Young-Ah; Ryu, Buom-Yong; Pang, Myung-Geol
- Issue Date
- Dec-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Eendocrine disruptors; Sperm function; Capacitation; Acrosome reaction; Estrogen; Progesterone; Heparin
- Citation
- REPRODUCTIVE TOXICOLOGY, v.32, no.4, pp 418 - 424
- Pages
- 7
- Journal Title
- REPRODUCTIVE TOXICOLOGY
- Volume
- 32
- Number
- 4
- Start Page
- 418
- End Page
- 424
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21059
- DOI
- 10.1016/j.reprotox.2011.09.011
- ISSN
- 0890-6238
- Abstract
- Xenoestrogenic compounds (XCs) can disrupt endogenous hormone function and affect sperm function by binding to receptors on sperm membrane. Albeit spermatozoa are potentially a useful model for screening estrogenic activities of endocrine disruptors, high-quality in vitro test system that examination of the XCs effects on sperm function is required. The objective of this study was to compare the effects of XCs (genistein and 4-tert-octylphenol) to those of steroids (estrogen and progesterone) and heparin on in vitro capacitation and acrosome reaction (AR) in mouse spermatozoa. Mouse spermatozoa were incubated with various concentrations (0.001-100 mu M) of each chemical for 15 or 30 min, and then capacitation and AR were assessed using chlortetracycline. All chemicals studied effectively alter capacitation and/or AR in mouse spermatozoa with different manner. Therefore, we believed that our system will provide a good in vitro model system to characterize the physiological effect of XCs especially when compared with steroids. (C) 2011 Elsevier Inc. All rights reserved.
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