Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system
- Authors
- Yoo, Na Young; Youn, Yu Seok; Oh, Nam Muk; Oh, Kyung Taek; Lee, Deok-Keun; Cha, Kyung-Hoi; Oh, Young Taik; Lee, Eun Seong
- Issue Date
- Nov-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Porous microparticle; Anthocyanin; Pulmonary delivery; Chronic obstructive pulmonary disease
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.88, no.1, pp 419 - 424
- Pages
- 6
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 88
- Number
- 1
- Start Page
- 419
- End Page
- 424
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21121
- DOI
- 10.1016/j.colsurfb.2011.07.024
- ISSN
- 0927-7765
1873-4367
- Abstract
- The purpose of this study was to fabricate porous poly(lactide-co-glycolide) (PLGA) microparticles for efficient pulmonary deposition and increased therapeutic duration of the antioxidant anthocyanin (ATH). These microparticles were prepared by a water-in-oil-in-water (W-1/O/W-2) multi-emulsion method with vaporizing ammonium bicarbonate (AB) as a porogen and starch as a viscous additive. High porosity achieved by the decomposition reaction of AB to the base of ammonia, carbon dioxide, and water vapor at 50 degrees C enabled efficient deposition of ATH throughout the entire lung in BALB/c mice. In addition, the porous microparticles incorporating starch showed sustained ATH release characteristics (up to 5 days) and protracted antioxidant activity (up to 5 days) for 2,2-diphenyl-1-pikryl-hydrazyl (DPPH) radicals, which was comparable to that of the porous microparticles without starch which completely released ATH in 2 h. Furthermore, these porous microparticles incorporating starch led to longer ATH residence (up to 20 days) in in vivo lung epithelium. We believe that this system has great pharmaceutical potential as a long-acting antioxidant for continuously relieving oxidative stress in pulmonary diseases like chronic obstructive pulmonary disease (COPD). (C) 2011 Elsevier B.V. All rights reserved.
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