A systematic review of metformin to limit weight-gain with atypical antipsychotics
- Authors
- Lee, Y. J.; Jeong, J. H.
- Issue Date
- Oct-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- atypical antipsychotic; metformin; weight-gain
- Citation
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, v.36, no.5, pp 537 - 545
- Pages
- 9
- Journal Title
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Volume
- 36
- Number
- 5
- Start Page
- 537
- End Page
- 545
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21195
- DOI
- 10.1111/j.1365-2710.2011.01255.x
- ISSN
- 0269-4727
1365-2710
- Abstract
- What is known and Objective: Weight-gain is commonly reported in patients taking atypical antipsychotic agents. A systematic review was performed to evaluate the effectiveness of metformin for attenuation of weight-gain induced by atypical antipsychotic agents. Methods: A PubMed database (1966-May 2010) search was conducted, using metformin, atypical antipsychotic and weight-gain as search terms. Review articles, letters and commentaries were excluded. Results and Discussion: Thirteen trials were identified (eight randomized, double-blind, placebo-controlled trials, one crossover adult trial, one open-label uncontrolled adult trial, two open-label uncontrolled paediatric trials and one case report). Of the eight randomized, double-blind, placebo-controlled trials, three studied adult subjects and one studied children. Metformin was well tolerated. The heterogeneity of the trials did not justify meta-analytic pooling of outcomes, and we provide a best evidence synthesis. What is new and Conclusion: There is limited evidence for the efficacy of metformin in limiting weight-gain induced by atypical antipsychotic agents. However, the evidence is weak and further well-powered randomized, double-blind, placebo-controlled studies of longer duration should be conducted to confirm the preliminary evidence and provide better estimates of effect.
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