The Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Indomethacin-induced Gastric Damage in Rats via Induction of Mucus Secretion and Down-regulation of ICAM-1 Expression
- Authors
- Yan, Xiang Mei; Joo, Min Jae; Lim, Jae Chun; Whang, Wan Kyun; Sim, Sang Soo; Im, Chaeuk; Kim, Hak Rim; Lee, Seok Yong; Kim, In Kyeom; Sohn, Uy Dong
- Issue Date
- Sep-2011
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Gastric damage; Mucus secretion; Intercellular adhesion molecule-1; Myeloperoxidase; Quercetin-3-O-beta-D-glucuronopyranoside; Interleukin-1 beta; Tumor necrosis factor-alpha
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.34, no.9, pp 1527 - 1534
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 34
- Number
- 9
- Start Page
- 1527
- End Page
- 1534
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21316
- DOI
- 10.1007/s12272-011-0915-4
- ISSN
- 0253-6269
1976-3786
- Abstract
- The mechanism of the protective effect of quercetin-3-O-beta-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-1 beta, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21316)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.