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Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch
- Issue Date
- 26-Jul-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- drug delivery; fibers; microstructures; polymeric materials; tissue engineering
- Citation
- ADVANCED MATERIALS, v.23, no.28, pp 3139 - +
- Journal Title
- ADVANCED MATERIALS
- Volume
- 23
- Number
- 28
- Start Page
- 3139
- End Page
- +
- ISSN
- 0935-9648
1521-4095
- Abstract
- An angiogenic microfiber patch that releases angiogenic growth factors along aligned fibers and subsequently directs the spacing and orientation of mature and functional blood vessel formation is presented. The fiber patches are prepared by electrostatically binding electrosprayed vascular endothelial growth factor (VEGF)-encapsulating poly(lactide-co-glycolide) (PLGA) microparticles with electrospun poly(lactide) (PLA) microfibers.
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