Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase
- Authors
- Seo, Jiyoung; Kang, Su-Il; Kim, Mihyang; Han, Jaehong; Hur, Hor-Gil
- Issue Date
- Jul-2011
- Publisher
- SPRINGER
- Keywords
- Biotransformation; Biphenyl dioxygenase; Naphthalene dioxygenase; Flavonoid; Polyphenol
- Citation
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.91, no.2, pp 219 - 228
- Pages
- 10
- Journal Title
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 91
- Number
- 2
- Start Page
- 219
- End Page
- 228
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21427
- DOI
- 10.1007/s00253-011-3334-z
- ISSN
- 0175-7598
1432-0614
- Abstract
- This review details recent progresses in the flavonoid biotransformation by bacterial non-heme dioxygenases, biphenyl dioxygenase (BDO), and naphthalene dioxygenase (NDO), which can initially activate biphenyl and naphthalene with insertion of dioxygen in stereospecfic and regiospecific manners. Flavone, isoflavone, flavanone, and isoflavanol were biotransformed by BDO from Pseudomonas pseudoalcaligenes KF707 and NDO from Pseudomonas sp. strain NCIB9816-4, respectively. In general, BDO showed wide range of substrate spectrum and produced the oxidized products, whereas NDO only metabolized flat two-dimensional substrates of flavone and isoflavone. Furthermore, biotransformation of B-ring skewed substrates, flavanone and isoflavanol, by BDO produced the epoxide products, instead of dihydrodiols. These results support the idea that substrate-driven reactivity alteration of the Fe-oxo active species may occur in the active site of non-heme dioxygenases. The study of flavonoid biotransformation by structurally-well defined BDO and NDO will provide the substrate structure and reactivity relationships and eventually establish the production of non-plant-originated flavonoids by means of microbial biotechnology.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21427)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.