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Cited 56 time in webofscience Cited 66 time in scopus
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The antidiabetic effect of ginsenoside Rb2 via activation of AMPK

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dc.contributor.authorLee, Kyoung-Tae-
dc.contributor.authorJung, Tae Woo-
dc.contributor.authorLee, Hak-Ju-
dc.contributor.authorKim, Seul-Gi-
dc.contributor.authorShin, Yu-Su-
dc.contributor.authorWhang, Wan-Kyunn-
dc.date.available2019-05-29T13:32:07Z-
dc.date.issued2011-07-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21444-
dc.description.abstractGinsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.titleThe antidiabetic effect of ginsenoside Rb2 via activation of AMPK-
dc.typeArticle-
dc.identifier.doi10.1007/s12272-011-0719-6-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.34, no.7, pp 1201 - 1208-
dc.identifier.kciidART001573272-
dc.description.isOpenAccessN-
dc.identifier.wosid000293460700021-
dc.identifier.scopusid2-s2.0-80052311046-
dc.citation.endPage1208-
dc.citation.number7-
dc.citation.startPage1201-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume34-
dc.type.docTypeArticle-
dc.publisher.location대한민국-
dc.subject.keywordAuthorPanax ginseng-
dc.subject.keywordAuthorRb2-
dc.subject.keywordAuthorAMPK-
dc.subject.keywordAuthorSHP-
dc.subject.keywordAuthorH4IIE cells-
dc.subject.keywordPlusENDOPLASMIC-RETICULUM STRESS-
dc.subject.keywordPlusPROTEIN-KINASE-
dc.subject.keywordPlusPANAX-GINSENG-
dc.subject.keywordPlusGLUCOSE-UPTAKE-
dc.subject.keywordPlusLIPID-METABOLISM-
dc.subject.keywordPlusLIVER-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusGLUCONEOGENESIS-
dc.subject.keywordPlusHEPATOCYTES-
dc.subject.keywordPlusAPOPTOSIS-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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