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The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
- Issue Date
- Jul-2011
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Panax ginseng; Rb2; AMPK; SHP; H4IIE cells
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.34, no.7, pp 1201 - 1208
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 34
- Number
- 7
- Start Page
- 1201
- End Page
- 1208
- ISSN
- 0253-6269
1976-3786
- Abstract
- Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.
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