The Relaxing Effect of alpha-Defensin 1 on the Adrenergic Responses of Rat Bladder
DC Field | Value | Language |
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dc.contributor.author | Lee, Shin Young | - |
dc.contributor.author | Kim, Don Kyu | - |
dc.contributor.author | Kim, Kyung Do | - |
dc.contributor.author | Myung, Soon Chul | - |
dc.contributor.author | Lee, Moo Yeol | - |
dc.date.available | 2019-05-29T13:33:50Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21514 | - |
dc.description.abstract | Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of alpha-defensin 1 on detrusor muscle contractions in isolated rat bladder. From the experiments we found relaxing effects of alpha-defensin 1 on the contractions induced by phenylephrine (PE) but not by bethanechol (BCh) in the detrusor smooth muscles. To determine the mechanisms of the effects of alpha-defensin 1, the changes of effects on PE-induced contraction by alpha-defensin 1 pretreatment were observed after pretreatment of Rho kinase inhibitor (Y-27632), protein kinase C (PKC) inhibitor (Calphostin C), potent activator of PKC (PDBu; phorbol 12,13-dibutyrate), and NF-kappa B inhibitors (PDTC; pyrrolidinedithiocarbamate and sulfasalazine). The contractile responses of PE (10(-9)similar to 10(-4) M) were significantly decreased in some concentrations of alpha-defensin 1 (5x10(-9) and 5x10(-9) M). When strips were pretreated with NF-kappa B inhibitors (PDTC and sulfasalazine; 10(-7)similar to 10(-6) M), the relaxing responses by alpha-defensin 1 pretreatment were disappeared. The present study demonstrated that alpha-defensin 1 has relaxing effects on the contractions of rat detrusor muscles, through NF-kappa B pathway. Further studies in vivo are required to clarify whether alpha-defensin 1 might be clinically related with bladder dysfunction by inflammation process. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | The Relaxing Effect of alpha-Defensin 1 on the Adrenergic Responses of Rat Bladder | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2011.15.3.143 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.15, no.3, pp 143 - 147 | - |
dc.identifier.kciid | ART001567905 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000292788600004 | - |
dc.identifier.scopusid | 2-s2.0-79960650115 | - |
dc.citation.endPage | 147 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 143 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | alpha-Defensin | - |
dc.subject.keywordAuthor | Detrusor smooth muscle | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Adrenergic system | - |
dc.subject.keywordPlus | MIGRATION INHIBITORY FACTOR | - |
dc.subject.keywordPlus | URINARY-TRACT-INFECTION | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBSTRUCTION | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | INNATE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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