Immunomodulatory activity of Lactobacillus strains isolated from fermented vegetables and infant stool
- Authors
- Won, Tae Joon; Kim, Bongjoon; Oh, Eun Seul; Bang, Joon Seok; Lee, Yoon Jeong; Yoo, Jong-Sun; Yu, Hyunmin; Yoon, Joowon; Hyung, Kyeong Eun; Park, So-Young; Hwang, Kwang Woo
- Issue Date
- Jun-2011
- Publisher
- CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
- Keywords
- Lactobacillus; fermented food; immunomodulation; T lymphocyte; B lymphocyte
- Citation
- CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, v.89, no.6, pp 429 - 434
- Pages
- 6
- Journal Title
- CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Volume
- 89
- Number
- 6
- Start Page
- 429
- End Page
- 434
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21528
- DOI
- 10.1139/Y11-047
- ISSN
- 0008-4212
1205-7541
- Abstract
- Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation.
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