A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato
DC Field | Value | Language |
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dc.contributor.author | Song, Hyuk-Hwan | - |
dc.contributor.author | Lee, Hee-Seok | - |
dc.contributor.author | Lee, Chan | - |
dc.date.available | 2019-05-29T13:34:27Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.issn | 1873-7072 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21537 | - |
dc.description.abstract | A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide, was produced by Fusarium solani KCCM90040, which was isolated from potato in Korea. The species of Fusarium was identified as F. solani by examining its morphological characteristics and by ITS-5.8rDNA sequence analysis. This compound was analysed for C33H52N4O6 by electrospray ionisation mass spectrometry and combined structural analysis. The one and two-dimensional NMR and the absolute configurations of amino acids spectral data allowed the resolution of five subunits linked in the following order: (S)-2-hydroxy-4-methylpentanoic acid, N-methyl-L-leucine, L-valine, L-leucine, and L-phenylalanine. The in vitro cytotoxic effect of the purified cyclic pentadepsipeptide was evaluated to establish the possibility that it would be a biohazard if present in foods. The concentrations of purified cyclic pentadepsipeptide required to inhibit cell growth in vitro by 50% for A549 (lung cancer), SK-OV-3 (ovarian cancer), SK-MEL-2 (skin melanoma), and MES-SA (uterine sarcoma) cell lines were 10.7 +/- 0.15, 11.2 +/- 1.23, 10.0 +/- 0.53, and 14.0 +/- 0.74 M, respectively (mean +/- SE). (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.foodchem.2010.11.023 | - |
dc.identifier.bibliographicCitation | FOOD CHEMISTRY, v.126, no.2, pp 472 - 478 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000286855200012 | - |
dc.identifier.scopusid | 2-s2.0-78650679779 | - |
dc.citation.endPage | 478 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 472 | - |
dc.citation.title | FOOD CHEMISTRY | - |
dc.citation.volume | 126 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Neo-N-methylsansalvamide | - |
dc.subject.keywordAuthor | Cyclic pentadepsipeptide | - |
dc.subject.keywordAuthor | Fusarium solani | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordPlus | ENNIATIN-H | - |
dc.subject.keywordPlus | GENUS FUSARIUM | - |
dc.subject.keywordPlus | MARINE FUNGUS | - |
dc.subject.keywordPlus | KFCC 11363P | - |
dc.subject.keywordPlus | BEAUVERICIN | - |
dc.subject.keywordPlus | OXYSPORUM | - |
dc.subject.keywordPlus | DEPSIPEPTIDE | - |
dc.subject.keywordPlus | SANSALVAMIDE | - |
dc.subject.keywordPlus | AVENACEUM | - |
dc.subject.keywordPlus | MK1688 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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