A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato
- Authors
- Song, Hyuk-Hwan; Lee, Hee-Seok; Lee, Chan
- Issue Date
- May-2011
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Neo-N-methylsansalvamide; Cyclic pentadepsipeptide; Fusarium solani; Cytotoxicity
- Citation
- FOOD CHEMISTRY, v.126, no.2, pp 472 - 478
- Pages
- 7
- Journal Title
- FOOD CHEMISTRY
- Volume
- 126
- Number
- 2
- Start Page
- 472
- End Page
- 478
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21537
- DOI
- 10.1016/j.foodchem.2010.11.023
- ISSN
- 0308-8146
1873-7072
- Abstract
- A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide, was produced by Fusarium solani KCCM90040, which was isolated from potato in Korea. The species of Fusarium was identified as F. solani by examining its morphological characteristics and by ITS-5.8rDNA sequence analysis. This compound was analysed for C33H52N4O6 by electrospray ionisation mass spectrometry and combined structural analysis. The one and two-dimensional NMR and the absolute configurations of amino acids spectral data allowed the resolution of five subunits linked in the following order: (S)-2-hydroxy-4-methylpentanoic acid, N-methyl-L-leucine, L-valine, L-leucine, and L-phenylalanine. The in vitro cytotoxic effect of the purified cyclic pentadepsipeptide was evaluated to establish the possibility that it would be a biohazard if present in foods. The concentrations of purified cyclic pentadepsipeptide required to inhibit cell growth in vitro by 50% for A549 (lung cancer), SK-OV-3 (ovarian cancer), SK-MEL-2 (skin melanoma), and MES-SA (uterine sarcoma) cell lines were 10.7 +/- 0.15, 11.2 +/- 1.23, 10.0 +/- 0.53, and 14.0 +/- 0.74 M, respectively (mean +/- SE). (C) 2010 Elsevier Ltd. All rights reserved.
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