Gastro-floating matrices designed for simultaneous improvement of floating and drug release capabilities: an in vitro case study of matrices loaded with ciprofloxacin hydrochloride
- Authors
- Shim, B. H.; Kim, D. K.; Ye, J. S.; Lee, J.
- Issue Date
- May-2011
- Publisher
- EDITIONS SANTE
- Keywords
- Floating; Gastro-retentive; Ciprofloxacin; Controlled release; Matrix
- Citation
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v.21, no.3, pp 279 - 281
- Pages
- 3
- Journal Title
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Volume
- 21
- Number
- 3
- Start Page
- 279
- End Page
- 281
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21555
- DOI
- 10.1016/S1773-2247(11)50038-3
- ISSN
- 1773-2247
- Abstract
- The aim of this study was to design gastro-retentive floating matrix tablets for ciprofloxacin hydrochloride (CFH) capable of releasing more than 80 % of the drug for 8 It with a floating time of longer than 8 h and a short floating lag time of less than 5 s. The matrices were prepared with 22 % sodium bicarbonate and a combination of hydroxypropylmethylcellulose (HPMC) and polyoxyethylene oxide (PEO). The tablets containing 22 % sodium bicarbonate could lead to immediate floating with floating lag times less than 5 s. Extended floating times of longer than 8 h and improved CFH release of more than 80 % for 8 h were achieved by the matrices prepared with 11% of HPMC 10K (Metolose 60SH 10,000) and PEO 1000K (PEO 1,000,000) mixture (5:5) containing 22 % sodium bicarbonate. From these results, this composition might be selected as a floating device for a prolonged deliver), of CFH in the stomach.
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