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Protein Expression Analysis in Hematopoietic Stem Cells during Osteopontin-Induced Differentiation of Natural Killer Cells
- Authors
- Kim, Mi Sun; Bae, Kil Soo; Kim, Hye-Jin; Yoon, Suk-Ran; Oh, Doo Byung; Hwang, Kwang Woo; Jun, Woo Jin; Shim, Sang In; Kim, Kwang-Dong; Jung, Yong-Woo; Park, So-Young; Kwon, Ki Sun; Choi, Inpyo; Chung, Jin Woong
- Issue Date
- 30-Apr-2011
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Osteopontin; Natural killer cells; Hematopoietic stem cells; Erk; Bcl-2
- Citation
- BIOMOLECULES & THERAPEUTICS, v.19, no.2, pp 206 - 210
- Pages
- 5
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 19
- Number
- 2
- Start Page
- 206
- End Page
- 210
- ISSN
- 1976-9148
2005-4483
- Abstract
- Natural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identified as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin alpha 9 was significantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN- induced NK differentiation.
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