Initial laboratory predictors of severe hepatitis and acute kidney injury in patients with acute hepatitis A
- Authors
- Cho, Sun Young; Choi, Seong-Ho; Park, Ji-Hoon; Chung, Jin-Won
- Issue Date
- Apr-2011
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Hepatitis A; Severe hepatitis A; Acute kidney injury
- Citation
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v.69, no.4, pp 400 - 404
- Pages
- 5
- Journal Title
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Volume
- 69
- Number
- 4
- Start Page
- 400
- End Page
- 404
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21624
- DOI
- 10.1016/j.diagmicrobio.2010.10.015
- ISSN
- 0732-8893
1879-0070
- Abstract
- The number of adult patients with acute hepatitis A (AH-A) has markedly increased during the last 10 years in Korea. Of special note, an increase in severe complications of AH-A, such as severe liver dysfunction and acute kidney injury (AKI), has emerged as a significant problem. The objective of this study was to identify the initial predictors for development of severe AH-A and AKI in AH-A. We retrospectively reviewed the medical records of 194 patients with AH-A from January 2007 to March 2009. Severe AH-A and AKI developed in 16 (9.3%) and 11(6.4%) patients, respectively. Independent predictors for severe AH-A were low albumin [odds ratio (OR), 10.91; 95% confidence interval (CI), 2.324-51.215; P = 0.002], low total cholesterol (OR, 5.54; 95% Cl, 1.389-22.113; P = 0.015), and elevated alanine aminotransferase (OR, 20.87; 95% Cl, 4.581-95.067; P < 0.001). Also, high level of C-reactive protein was independently associated with AKI occurrence in AH-A (OR, 10.91; 95% Cl, 2.324-51.215; P = 0.002). (C) 2011 Elsevier Inc. All rights reserved.
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