Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyoung-Tae | - |
dc.contributor.author | Nam, Taek-Kyun | - |
dc.contributor.author | Park, Yong-Sook | - |
dc.contributor.author | Kim, Young-Baeg | - |
dc.contributor.author | Park, Seung-Won | - |
dc.date.available | 2019-05-29T13:37:54Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 2005-3711 | - |
dc.identifier.issn | 1598-7876 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21650 | - |
dc.description.abstract | Objective : We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats, Methods : The animals were divided into two groups : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-beta-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups. Results : At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7 +/- 3.4%, platform hang by 40.0 +/- 9.1% and hind foot bar grab by 30.8 +/- 8.4% (p < 0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98 +/- 0.38) than the control group (1.34 +/- 0.24) (p < 0.05). The lesion volume in lesion periphery was 32.1 +/- 2.4 mu L in the control and 24.5 +/- 2.3 mu L in the AT group, respectively (p < 0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3 +/- 5.1 cells/HPF in the control and 13.4 +/- 6.3 cells/HPF in the AT group, respectively (p < 0.05). Conclusion : Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NEUROSURGICAL SOC | - |
dc.title | Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury | - |
dc.type | Article | - |
dc.identifier.doi | 10.3340/jkns.2011.49.4.205 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, v.49, no.4, pp 205 - 211 | - |
dc.identifier.kciid | ART001552076 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000290468300001 | - |
dc.identifier.scopusid | 2-s2.0-79957856257 | - |
dc.citation.endPage | 211 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 205 | - |
dc.citation.title | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | - |
dc.citation.volume | 49 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Spinal cord trauma | - |
dc.subject.keywordAuthor | Anthocyanin | - |
dc.subject.keywordAuthor | Antioxidants | - |
dc.subject.keywordPlus | HYDROXYL RADICAL FORMATION | - |
dc.subject.keywordPlus | PNEUMATIC IMPACT DEVICE | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | EDARAVONE MCI-186 | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.