Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury
- Authors
- Kim, Kyoung-Tae; Nam, Taek-Kyun; Park, Yong-Sook; Kim, Young-Baeg; Park, Seung-Won
- Issue Date
- Apr-2011
- Publisher
- KOREAN NEUROSURGICAL SOC
- Keywords
- Spinal cord trauma; Anthocyanin; Antioxidants
- Citation
- JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, v.49, no.4, pp 205 - 211
- Pages
- 7
- Journal Title
- JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
- Volume
- 49
- Number
- 4
- Start Page
- 205
- End Page
- 211
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21650
- DOI
- 10.3340/jkns.2011.49.4.205
- ISSN
- 2005-3711
1598-7876
- Abstract
- Objective : We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats, Methods : The animals were divided into two groups : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-beta-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups. Results : At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7 +/- 3.4%, platform hang by 40.0 +/- 9.1% and hind foot bar grab by 30.8 +/- 8.4% (p < 0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98 +/- 0.38) than the control group (1.34 +/- 0.24) (p < 0.05). The lesion volume in lesion periphery was 32.1 +/- 2.4 mu L in the control and 24.5 +/- 2.3 mu L in the AT group, respectively (p < 0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3 +/- 5.1 cells/HPF in the control and 13.4 +/- 6.3 cells/HPF in the AT group, respectively (p < 0.05). Conclusion : Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.