A functional promoter polymorphism-607G > C of WNT10B is associated with abdominal fat in Korean female subjects
DC Field | Value | Language |
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dc.contributor.author | Kim, Il Chul | - |
dc.contributor.author | Cha, Min Ho | - |
dc.contributor.author | Kim, Dong Min | - |
dc.contributor.author | Lee, Haeyong | - |
dc.contributor.author | Moon, Jin Seok | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Kim, Kil Soo | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.available | 2019-05-29T13:38:47Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.issn | 1873-4847 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21683 | - |
dc.description.abstract | WNT10B has been implicated as a potential regulator of adipogenesis in cellular and animal models of obesity. In this study, we attempted to characterize the associations between common genetic polymorphisms of WNT10B and fat accumulation in a sample of 1029 Korean female subjects. Direct sequencing of genomic DNAs of 45 subjects identified six common single-nucleotide polymorphisms (SNPs) of WNT10B, which were in almost complete linkage disequilibrium. Among the six SNPs, -607G>C (rs833840) showed differential nuclear factor binding in an electrophoretic mobility shift assay and differential promoter activity in a reporter assay, implicating it as a functional regulatory SNP. When body compositions of the subjects determined using bio-impedance analysis were compared according to their -607G>C genotype, only body fat mass showed a significant association. Body masses of protein, mineral and water showed no association. For more accurate evaluation of the effects of -607G>C genotype on body fat, cross-sectional fat areas of the subjects measured by abdominal computed tomography were compared. Genotype of -607G>C was significantly associated with abdominal total fat and abdominal subcutaneous fat areas (P=.009 and P=.007 in recessive model, respectively). Of the 1029 subjects, 576 were treated with a 1 month very low calorie diet and changes of body weight and composition were compared with -607G>C genotype. No significant associations were evident. This study is the first report of the association of common genetic polymorphism of WNT10B with human fat accumulation. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | A functional promoter polymorphism-607G > C of WNT10B is associated with abdominal fat in Korean female subjects | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jnutbio.2010.02.002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.22, no.3, pp 252 - 258 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000288364200007 | - |
dc.identifier.scopusid | 2-s2.0-79951674549 | - |
dc.citation.endPage | 258 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 252 | - |
dc.citation.title | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | WNT10B | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | SNP | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Fat | - |
dc.subject.keywordAuthor | Association | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | BONE MASS | - |
dc.subject.keywordPlus | BODY-FAT | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | OSTEOBLASTOGENESIS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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