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A Smart Polysaccharide/Drug Conjugate for Photodynamic Therapy
- Authors
- Park, So Young; Baik, Hye Jung; Oh, Young Taik; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
- Issue Date
- 11-Feb-2011
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- drug delivery; imaging agents; photodynamic therapy; polysaccharides
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.50, no.7, pp 1644 - 1647
- Pages
- 4
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 50
- Number
- 7
- Start Page
- 1644
- End Page
- 1647
- ISSN
- 1433-7851
1521-3773
- Abstract
- Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pHa value and was shown to penetrate HeLa tumors in mice as determined by fluorescence imaging. It has the potential to be used in photodynamic therapy, thereby targeting the tumor while having no detrimental effects on the surrounding tissue. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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