Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-kappa B activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Dae-Seok | - |
dc.contributor.author | Kim, Bora | - |
dc.contributor.author | Tahk, Hongmin | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Ahn, Eu-Ree | - |
dc.contributor.author | Choi, Changsun | - |
dc.contributor.author | Jeon, Yoon | - |
dc.contributor.author | Park, Seo Young | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Kim, Soo-Youl | - |
dc.date.available | 2019-05-30T00:36:21Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22008 | - |
dc.description.abstract | Transglutaminase 2 knockout (TGase2(-/-)) mice show significantly reduced inflammation with decreased myofibroblasts in a unilateral ureteral obstruction (UUO) model, but the mechanism remains to be clarified. Nuclear factor-kappa B (NF-kappa B) activation plays a major role in the progression of inflammation in an obstructive nephropathy model. However, the key factors extending the duration of NF-kappa B activation in UUO are not known. In several inflammatory diseases, we and others recently found that TGase 2 plays a key role in extending NF-kappa B activation, which contributes to the pathogenesis of disease. In the current study, we found that NF-kappa B activity in mouse embryogenic fibroblasts (MEFs) from TGase2(-/-) mice remained at the control level while the NF-kappa B activity of wild-type (WT) MEFs was highly increased under hypoxic stress. Using the obstructive nephropathy model, we found that NF-kappa B activity remained at the control level in TGase2(-/-) mouse kidney tissues, as measured by COX-2 expression, but was highly increased in WT tissues. We conclude that TGase 2 gene ablation reduces the duration of NF-kappa B activation in ischemic injury. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-kappa B activation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.11.063 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.403, no.3-4, pp 479 - 484 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000286021300040 | - |
dc.identifier.scopusid | 2-s2.0-78650170689 | - |
dc.citation.endPage | 484 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 479 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 403 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Transglutaminase 2 | - |
dc.subject.keywordAuthor | Transglutaminase 2 knockout mouse | - |
dc.subject.keywordAuthor | Unilateral ureteral obstruction | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Renal injury | - |
dc.subject.keywordPlus | UNILATERAL URETERAL OBSTRUCTION | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | TISSUE TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | DIABETIC-NEPHROPATHY | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | BLOOD MONOCYTES | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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